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NFL Draft 2026 Five Guaranteed First-Round Picks
Photo: Jan 20, 2025; Atlanta, GA, USA; Notre Dame Fighting Irish wide receiver Jordan Faison (6) against Ohio State Buckeyes safety Caleb Downs (2) during the CFP National Championship college football game at Mercedes-Benz Stadium. Mandatory Credit: Mark J. Rebilas-

NFL Draft 2026 Five Guaranteed First-Round Picks

Teams across the NFL are studying college tape, mock drafts and advanced metrics to determine which players deserve the highest selections when the NFL Draft begins in Pittsburgh on April 23.

Operators of the betting sites listed on Bettingtop10.com will be keeping a close eye on developments, as the draft has the potential to shape sportsbook odds for next season.

With that in mind, read on as we look at five players whose elite production, physical traits and positional value will garner attention from NFL teams and oddsmakers.

Fernando Mendoza

Quarterback Fernando Mendoza transformed Indiana’s offense during the 2025 season and quickly became one of the most talked-about players in college football.

Mendoza’s rapid rise has pushed him into contention for the number-one overall selection. Scouts are drawn to his arm strength and confidence in pushing the ball downfield.

He has the size and durability that teams want in a franchise quarterback. He also shows impressive poise in the pocket, remaining calm even when facing pressure.

Analysts have pointed out that his combination of leadership and physical tools gives him the ceiling of a long-term starter in the NFL.

That combination has made him a favourite to be selected near the top of the draft.

Kelvin Banks Jr

With many top tackles from the previous class already in the NFL, Texas offensive lineman Kelvin Banks Jr has become the leading tackle prospect for the 2026 draft.

Banks is the anchor for one of the most effective offensive lines in college football. Scouts consistently highlight his balance and footwork in pass protection.

His ability to mirror fast edge rushers allows him to keep defenders away from the quarterback’s blind side. That trait is extremely valuable in a league where elite pass rushers dominate defensive schemes.

Banks also brings impressive power in the run game. He has the strength to drive defenders off the line of scrimmage. His combination of size, athleticism and experience makes him one of the safest picks available.

For teams looking to protect a young quarterback, Banks is widely viewed as a plug-and-play starter.

Arvell Reese

Ohio State defender Arvell Reese is the type of modern defensive prospect that NFL teams increasingly value.

Reese has the rare ability to contribute in several different roles. He can rush the passer off the edge, drop into coverage against tight ends and even defend mobile quarterbacks in space. That versatility has made him one of the most intriguing defensive players in the class.

Reese’s athleticism jumps off the screen when watching his college film. He closes quickly on ball carriers and has the speed to chase plays from sideline to sideline.

Scouts also praise his instincts and awareness in recognising offensive formations. Those qualities allow him to anticipate plays before they fully develop.

Because modern NFL defences rely heavily on adaptable players, Reese projects as a potential cornerstone defender. That value alone should guarantee him a place among the earliest selections.

Tetairoa McMillan

Arizona wide receiver Tetairoa McMillan is widely considered the top pass-catcher in the 2026 class.

He presents an enormous target for quarterbacks. His height and wingspan allow him to dominate contested catches. That ability has earned him comparisons to NFL receivers such as Mike Evans.

McMillan’s production at Arizona has backed up those comparisons. He consistently wins one-on-one match-ups and provides a reliable red-zone threat.

Scouts also appreciate that he is more than just a jump-ball specialist. His route running and body control allow him to create separation against high-level defenders.

Those traits give him the potential to become a true number-one receiver at the next level. Players with McMillan’s skill set are extremely valuable and he should be a first-round pick.

Caleb Downs

Caleb Downs has done enough to establish himself as one of the most dependable players coming out of college football in this draft.

The Ohio State defensive back has built a reputation as a complete secondary presence who can impact both the run and pass.

He tackles with authority, reads the game with intelligence and moves well enough to remain effective in coverage. That combination gives him a high floor and a strong projection at the professional level.

Teams value players who minimise mistakes while still offering playmaking upside, and Downs fits that description.

He may not carry the same headline appeal as quarterbacks or pass rushers, but his consistency and positional awareness make him a dependable first-round draft candidate.